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Extracellular histones as biomarkers for prognosis and molecular targets for therapy
Extracellular histones as biomarkers for prognosis and molecular targets for therapy
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机译:细胞外组蛋白作为预后的生物标志物和治疗的分子靶标
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摘要
Hyper-inflammatory responses can lead to a variety of diseases including sepsis. It is now shown that extracellular histones released in response to inflammatory challenge are mediators contributing to endothelial dysfunction, organ failure and death during sepsis. As such, they can be targeted pharmacologically by inhibitors, as well as used as biomarkers for prognosis of sepsis and other diseases.
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