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METHODS OF TREATING A SUBJECT HAVING GLYCOGEN STORAGE DISEASE WITH mRNA ENCODING GLUCOSE-6-PHOSPHATASE CATALYTIC SUBUNIT (G6PC)
METHODS OF TREATING A SUBJECT HAVING GLYCOGEN STORAGE DISEASE WITH mRNA ENCODING GLUCOSE-6-PHOSPHATASE CATALYTIC SUBUNIT (G6PC)
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机译:编码葡萄糖-6-磷酸酶催化亚单位(G6PC)的mRNA治疗患有糖原贮积病的对象的方法
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摘要
The present invention relates to a complexed RNA, comprising at least one RNA complexed with one or more oligopeptides, wherein the oligopeptide has a length of 8 to 15 amino acids and has the empirical formula (Arg)l;(;Lys)m;(His)n;(Orn)o;(Xaa)x. The invention further relates to a method for transfecting a cell or an organism, thereby applying the inventive complexed RNA. Additionally, pharmaceutical compositions and kits comprising the inventive complexed RNA, as well as the use of the inventive complexed RNA for transfecting a cell, tissue or an organism and/or for modulating, preferably inducing or enhancing, an immune response are disclosed herein.
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机译:本发明涉及一种复合RNA,其包含至少一种与一种或多种寡肽复合的RNA,其中所述寡肽的长度为8至15个氨基酸,并具有经验式(Arg) 1 Sub>; (; Lys) m Sub>;(His) n Sub>;(Orn) o Sub>;(Xaa) x Sub>。本发明进一步涉及转染细胞或生物体,从而应用本发明的复合RNA的方法。另外,本文公开了包含本发明的复合RNA的药物组合物和试剂盒,以及本发明的复合RNA在转染细胞,组织或生物体中和/或用于调节,优选诱导或增强免疫应答的用途。
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