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An Optical Detection Based on Non-Linear Magnetophoretic Transport of Magnetic Particle for Particle and Biological Sensing and Separation
An Optical Detection Based on Non-Linear Magnetophoretic Transport of Magnetic Particle for Particle and Biological Sensing and Separation
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机译:基于磁性粒子的非线性磁致动输运的粒子光学检测与生物传感与分离
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摘要
There is provided system and a separation substrate device for use with an NLM separator in separating and/or detecting at least one target analyte in a sample, the substrate comprising a micromagnet array of a plurality of micromagnets, the micromagnet array comprising a first capture region, a second focussing region, and, a third detection region, the focussing region comprising a converging and/or diverging micromagnet array region. Also provided is a method for separating and detecting at least one target analyte in a sample. The method including: contacting a plurality of magnetic beads with a sample, the magnetic beads functionalized for binding with one or more target analytes in a sample to form aggregates; providing the sample including magnetic beads and aggregates to a separating substrate comprising a micromagnet array of a plurality of micromagnets; transporting the magnetic beads and aggregates relative to the micromagnet array to provide separation and enable detection of the magnetic beads and aggregates; detecting motion of the beads or aggregates of the sample on the array in response to the applied magnetic field and/or detecting beads or aggregates of the sample on the array at a detection region of the array.
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