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Mouse model of alpha-one antitrypsin (AAT) deficiency
Mouse model of alpha-one antitrypsin (AAT) deficiency
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机译:α一抗胰蛋白酶(AAT)缺乏症的小鼠模型
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摘要
Transgenic non-human animals, e.g., rodents, e.g., mice comprising genomic mutations that inactive all of the serpin1A genes and thus lack any functional serpinA1 genes. As a result of the genomic mutations, the animals express no hepatic or circulatory AAT protein. Also provided herein are cells and tissues derived from the transgenic mice.
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