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BIOMARKERS OF RESPONSE TO SELECTIVE INHIBITORS OF AURORA A KINASE
BIOMARKERS OF RESPONSE TO SELECTIVE INHIBITORS OF AURORA A KINASE
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机译:对极光激酶选择性抑制剂的反应的生物标志物
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摘要
Disclosed herein are WNT and Hippo pathway markers associated with sensitivity to treatment with Aurora A kinase inhibitors. Claimed genes include LEF1, MAP3K7, APC, FZD2, PRKCA, RORA, CAMK2G, JUN, XP01, ROR2, CCND1 & CTNNB1 (WNT pathway) and AMOT, DVL2, LATS1, LATS2, MOB1 B, NPHP4, TJP1, TJP2, WCC1, WWTR1 & YAP1 (Hippo pathway). Sensitivity to treatment with an Aurora A kinase inhibitor is observed when the aforementioned markers have mutations in tumor cells. Compositions and methods are provided to assess marker genes to predict response to Aurora Kinase A inhibition treatment and for patient selection.
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