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GPCR (GPR113) INVOLVED IN FAT, FATTY ACID AND/OR LIPID-ASSOCIATED TASTE AND USE IN ASSAYS FOR IDENTIFYING TASTE MODULATORY
GPCR (GPR113) INVOLVED IN FAT, FATTY ACID AND/OR LIPID-ASSOCIATED TASTE AND USE IN ASSAYS FOR IDENTIFYING TASTE MODULATORY
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机译:GPCR(GPR113)涉及脂肪,脂肪酸和/或脂类相关口味,并用于鉴定口味调制
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摘要
This invention relates to a gene encoding a GPR113, wherein GPR113 is a taste receptor polypeptide which detects fat tastants. In one embodiment the invention relates to the use of the GPR113 receptor in screening assays for identifying fat, lipid and fatty acid taste modulators or compounds that mimic fat taste. In another embodiment the invention relates a method for reducing dietary preferences for fat containing foods, comprising administering to a subject a compounds which modulates GPR113. In another embodiment the invention relates to comestibles containing an amount of a compound that specifically binds or modulates GPR113 activity, e.g. a GPR113 enhancer or GPR113 blocker, in an amount sufficient to modulate or mimic fat or lipid taste or to affect fat or lipid metabolism.
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