PROMOTING AXON RENEGERATION IN THE ADULT CNS THROUGH CONTROL OF PROTEIN TRANSLATION

摘要

Disclosed are methods for promoting survival of, or axon regeneration in a lesioned mature central nervous system (CNS) by contacting the neuron with a therapeutically effective amount of an exogenous activator of protein translation. Detecting the resultant promotion of the survival of, or axon regeneration in the neuron may further be performed. The methods may be performed using an inhibitor of phosphatase and tensin homolog (PTEN). Pharmaceutical compositions and preloaded devices for use in the methods are also disclosed.