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METHOD FOR PRODUCING ANTIBODY CH3 DOMAIN HETERODIMERIC MUTANT PAIR USING YEAST MATING AND CH3 MUTANT PAIR PRODUCED THEREBY
METHOD FOR PRODUCING ANTIBODY CH3 DOMAIN HETERODIMERIC MUTANT PAIR USING YEAST MATING AND CH3 MUTANT PAIR PRODUCED THEREBY
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机译:利用酵母菌生产抗体的ch3域异二聚体突变体的方法及由此产生的ch3突变体对
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摘要
A method for evaluating and screening a mutant inducing the high-efficiency formation of heterodimers from a human antibody heavy chain constant region mutant pair combination library in order to increase the yield of formation of human antibody heterodimeric heavy chain constant regions. A heterodimeric heavy chain constant region (heterodimeric F) library is obtained by the method. A CH3 domain mutant pair, in which the formation of the heterodimeric heavy chain constant regions is preferred in the library, forms heterodimeric heavy chain constant regions at a high yield of at least 80-90%, and also has excellent thermal stability and retains binding ability to the heavy chain constant region receptor (FcRn).
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