composition and method of production of immunoadjuvant nanoparticulate systems in the production of neutralizing sera against toxins from venomous animals

摘要

The invention relates to the composition and preparation technique of nanoparticulate systems as well as to the process of obtaining sera for neutralizing toxins from venomous animals including, snakes, scorpions, centipedes, spiders, bees, caterpillars, wasps, frogs. , frogs, cnidaria and arthropods, using these poly (lactic acid) (pla) and / or poly-lactic-co-glycolic acid (plga) nanoparticulate systems as immunoadjuvant, characterized by hyperbranched polyethyleneimine functionalized nanoparticles and stabilized by a surfactant containing the venom and / or venom proteins obtained by the solvent displacement / nanoprecipitation and / or solvent evaporation emulsification method to provide a novel immunoadjuvant for immunization of animals, particularly goats or horses, subcutaneous or intradermal route for the production of poisonous sera from venomous animals.