recombinant bacteriophage, recombinant bacteriophage genome polynucleotide, pharmaceutical composition, vaccine, and method for treating an infectious disease.

摘要

The present invention describes a recombinant bacteriophage comprising a phage genome polynucleotide including a gene encoding a heterologous antigenic protein (s) and an exterminator gene encoding a protein that is capable of exterminating a bacterium hostess. A recombinant bacteriophage such as this is designed to prepare an individual's immune response and to exterminate the bacterium it infects, such that the? prepare and exterminate? provide two lines of protection against infectious disease.