artificial antigen-presenting cell, method for expanding tumor infiltrating lymphocytes, treating cancer with a population of tumor infiltrating lymphocytes and for assessing the power of tumor infiltrating lymphocytes, kit, tumor infiltrating lymphocyte population, and, combination

摘要

in some embodiments, compositions and methods related to isolated antigen presenting artificial cells (aapcs) are disclosed, including aapcs comprising a myeloid cell transduced with one or more viral vectors, such as a molm-14 or an em-3 myeloid cell, wherein the endogenously myeloid cell expresses hla-a / b / c, icos-1, and cd58, and wherein the one or more viral vectors comprise a cd86-encoding nucleic acid and a 4-1bbl and / or ox40l-encoding nucleic acid and transduce the myeloid cell to express cd86 and 4-1bbl and / or ox401 proteins. In some embodiments, methods of expanding tumor infiltrating lymphocytes (t115) with aapcs and methods of treating cancers using thyls after expansion with aapcs are also disclosed.