photosensitizing agent or a pharmaceutically acceptable salt thereof, process for the preparation thereof, pharmaceutical composition, use of said agent or a pharmaceutically acceptable salt thereof, method for introducing a transfer molecule into the cytosol of a cell, method for photochemotherapeutic treatment of disorders or abnormalities of the external or internal surfaces of the body, product, kit for use in photochemotherapy of disorders or abnormalities of the external or internal surfaces of the body, and method for in vitro diagnosis of abnormalities or disorders by analyzing a sample fluid from a patient's body or tissue

摘要

photosensitizing agent or a pharmaceutically acceptable salt thereof, process for preparing it, pharmaceutical composition, use of said agent or a pharmaceutically acceptable salt of the same method for introducing a transfer molecule into the cytosol of a cell, method for treatment photochemotherapy of disorders or abnormalities of the external or internal surfaces of the body, product, kit for use in photochemotherapy of disorders or abnormalities of the external or internal surfaces of the body, and method for in vitro diagnosis of abnormalities or disorders by analyzing a sample of the In a patient's body or tissue fluid the present invention features photosensitizing agents obtained by reducing a single double bond in the porphyrin macrocycle of a sulfonated porphyrin meso-tetrafenyl, preferably a disulfonated porphyrin mesotetrafenyl as tpps-2a-. The resulting sulfonated meso-tetrafenyl chlorines include compounds of formula (i)). (where x is -so ~ 3-h; n, p, q and q are each independently 0 or 1; and the sum of n, p, q and q is an integer from 1 to 4, preferably at least 2, as 2 or 4) isomers and mixtures of isomers thereof. The compounds of the invention and their pharmaceutically acceptable salts find special use as photosensitizing agents in photochemical internalization of molecules and photodynamic therapy.