DIPEPTIDE REPEAT PROTEINS AS A THERAPEUTIC TARGET IN NEURODEGENERATIVE DISEASES WITH HEXANUCLEOTIDE REPEAT EXTENSION

摘要

The present invention relates to a method of detecting a disease characterized by an expansion of genomic hexanucleotide repeats as well as polypeptides of said hexanucleotide repeats, ligands specifically binding to the polypeptide, methods of identifying an inhibitor preventing the expression and/or aggregation of said polypeptide.