DEVICE AND METHOD FOR QUANTIFICATION OF CORPUSCULATE AND NON -CORPUSCULATE SUBSTANCES OF BLOOD.

摘要

Device (1) for the quantification of cellular and non-cellular components (3, 3', 3") in a solution containing a blood sample comprising: at least one pair of detection electrodes (4, 4', 5, 5', 6, 6', 34, 34'), said at least one pair of detection electrodes (4, 4', 5, 5', 6, 6', 34, 34') comprising at least one first electrode (4, 5, 6, 34) connected with a first input apt to receive a first signal in input (V+) and a second electrode (4', 5', 6', 34'); at least one pair of reference electrodes (7, 7', 8, 8', 9, 9', 37, 37'), said at least one pair of reference electrodes (7, 7', 8, 8', 9, 9', 37, 37') comprising a first electrode (7, 8, 9, 37) connected with a second input configured to receive a second signal in input (V-) of opposite polarity to the first input signal (V+) and a second electrode (7', 8', 9', 37') connected to the second electrode (4', 5', 6', 34') of said at least one pair of detection electrodes (4, 4', 5, 5', 6, 6', 34, 34'), in a common point wherefrom an output signal (Out) is picked up; at least one concentrator (10, 10', 10", 14, 14', 14") of ferromagnetic material, configured to co-operate with a magnetic field external to the device (1), in such a way as to cause the concentration of said components (3, 3', 3") on said at least one pair of detection electrodes (4, 4', 5, 5', 6, 6', 34, 34'); a substrate (11) configured for the housing of: said at least one pair of detection electrodes (4, 4', 5, 5', 6, 6', 34, 34'), said at least one pair of reference electrodes (7, 7', 8, 8', 9, 9', 37, 37') and said at least one concentrator (10, 10', 10", 14, 14', 14"); a support (12) configured to collect a sample of blood or of solution containing blood; at least one spacer element (13, 13') configured to confine in the plane of the substrate the blood sample and to distance said substrate (11) from said support (12). The device can be applied to the diagnosis of all those pathologies that cause an alteration of the magnetic properties of one or more types of blood cells and/or give rise to the formation of substances with different magnetic properties from plasma, said substances being absent or in a different concentration in physiological conditions