DRUG DESIGN FOR APPLICATION-DEPENDENT PAYLOAD, CONTROLLED PHARMACOKINETIC DISTRIBUTION, AND RENAL CLEARANCE

摘要

Design and use of an administered drug in the form of a nanoparticle or molecule is described. In certain examples, the nanoparticle has a core and a shell surrounding the core. The core may be configured or designed to provide useful X-ray attenuating properties, gamma ray emission properties, magnetic properties, or therapeutic effects. The nanoparticle or molecule either has a size range minimum larger than about 3-4 nm and a size range maximum smaller than about 5-6 nm so as to remain in the blood pool during imaging or has a size range maximum selected to be smaller than about 3-4 nm so as to distribute from the blood pool during imaging, while still being eliminated by the kidneys.