ANTIBODY-DRUG CONJUGATES INCLUDING ANTIBODY AGAINST EGFRVIII

摘要

The present invention relates to: novel antibody-drug conjugates (ADC) targeting EGFRvIII; a metabolite for activating the ADCs; a method for producing the ADCs; uses of the ADCs to treat and/or prevent diseases; and uses of the ADCs to produce drugs for treating and/or preventing diseases, more specifically, hyperplasia and/or angiogenesis for example, and cancerous diseases. More specifically, the present invention relates to: an antibody-drug conjugate which includes an antibody binding to epidermal growth factor receptor variant III (EGFRvIII), or includes an antigen-binding fragment of the antibody; and a pharmaceutical composition including same.