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Anti-gremlin-1 (GREM1) antibodies and methods of use thereof for treating pulmonary arterial hypertension
Anti-gremlin-1 (GREM1) antibodies and methods of use thereof for treating pulmonary arterial hypertension
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机译:抗gremlin-1(GREM1)抗体及其用于治疗肺动脉高压的方法
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摘要
The present invention provides anti-Gremlin-1 (GREM1) antibodies, and antigen-binding fragments thereof, as well as methods of use of such antibodies, or antigen-binding fragments thereof, for treating a subject having pulmonary arterial hypertension (PAH). It is disclosed a method of treating a subject having pulmonary arterial hypertension (PAH), comprising administering to the subject a therapeutically effective amount of an anti-gremlin-1 (GREM1) antibody, or antigen-binding fragment thereof, wherein the therapeutic effect of administration of the anti-GREMl antibody, or antigen-binding fragment thereof, to the subject is selected from the group consisting of inhibiting thickening of the pulmonary artery in the subject; increasing stroke volume in the subject; increasing right ventricle cardiac output in the subject; and extending survival time of the subject, thereby treating the subject having PAH.
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