COMPOUNDS CONTAINING POLYSUBSTITUTED BENZOD1,3OXATHIOLE, BENZOD1,3OXATHIOLE 3-OXIDE OR BENZOD1,3OXATHIOLE 3,3-DIOXIDE AND METHODS/USES THEREOF AS AGONISTS OF G PROTEIN-COUPLED RECEPTOR 119

摘要

There are provided compounds having formula (I), in which: X¹ and X² are selected from certain combinations of O, S, SO and SO₂; X³ is selected from CH, CF and N; X⁴ is selected from CH and N; X⁶, X^6' and X^6'' are selected from H, halogen, and certain alkyl, haloalkyl, alkoxy, hydroxyalkyl, and amide groups; X⁷ and X^7' are selected from H, halogen, and certain alkyl, haloalkyl, alkoxy, hydroxyalkyl, aminoalkyl and amide groups, or both X⁷ and X^7' together form a cycloalkyl or heterocycle; and A is selected from certain optionally substituted, alkoxy, piperazinyl and pyrrolidinyl groups. Also provided are compositions comprising these compounds, as well as uses/methods related thereto, including treatment of diseases and conditions associated with GPR119 dysregulation, Type 2 diabetes mellitus, and related metabolic disorders. (I)