CD3-NEGATIVE CELL POPULATION EXPRESSING CHEMOKINE RECEPTOR AND CELL ADHESION MOLECULE, USE THEREOF, AND METHOD FOR PRODUCING SAME

摘要

The present invention pertains to immune cells having higher cytotoxic activity, and a pharmaceutical composition for performing highly effective NK cell therapy. The present invention provides a cell population containing cells that are CCR5-positive, CCR6-positive, CXCR3-positive, and CD3-negative. The present invention provides a cell population in which cells that are CCR5-positive, CCR6-positive, CXCR3-positive, and CD3-negative furthermore express a high level of CD11c. The present invention provides cells that invade solid tumors and are CCR5-positive, CCR6-positive, CXCR3-positive, and CD3-negative. The present invention also provides a pharmaceutical composition containing such a cell population and a pharmacologically acceptable additive. Furthermore, the present invention provides a method for producing the cell population.