ENGINEERED DECARBOXYLASE POLYPEPTIDES AND USES THEREOF IN PREPARING TYRAMINE AND DOPAMINE

摘要

Provided herein are engineered decarboxylase polypeptides that are useful for catalyzing the decarboxylation of amino aicds such as L-tyrosine to produce tyramine or catalyzing the decarboxylation of L-DOPA to produce dopamine. Also provided is the preparation process of the engineered decarboxylase polypeptides as well as reaction process under industrial-relevant conditions. Also provided are polynucleotide sequences encoding the engineered decarboxylase polypeptides, and methods of producing tyramine or dopamine using the engineered decarboxylase polypeptides.