A METHOD OF ASSESSMENT OF MICROCIRCULATION OSCILLATIONS AND DEVICE THEREFOR

摘要

A method of assessment of microcirculation oscillations comprises illumination of a selected location on non-hairy skin of a human subject in a resting steady condition without any blockage or stimulation of the blood flow with exciting light capable of inducing skin NADH fluorescence signal for a period of time; simultaneously with said illumination detecting, measuring and recording as a function of time the induced NADH fluorescence signal emitted from the said selected location to obtain the time course of the NADH fluorescence signal intensity in the said period of time; and computer implemented steps of:fitting of a baseline about which the NADH fluorescence signal oscillates to the said time course of the NADH fluorescence signal; and determination of a mean squared error of the deviation of the NADH fluorescence signal from the fitted baseline as a parameter of oscillatory function of the skin microcirculation.