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IMMUNE EFFECTOR CELLS AND MOLECULAR ADAPTORS WITH AN ANTIGEN-CYTOKINE COMPLEX FOR EFFECTIVE IMMUNOTHERAPY

机译:带有抗原-细胞因子复合物的免疫效应细胞和分子适配器,可用于有效的免疫治疗

摘要

Embodiments of the disclosure encompass methods and compositions related to cancer treatment with particular immune effector cells as adoptive immunotherapy and/or with soluble proteins to which the immune effector cells are able to bind. In some cases, the soluble proteins are molecular adaptors that allow targeting of cancer cells that lack expression of a tumor antigen to which the adoptive immunotherapy is directed. In some embodiments, the soluble proteins are exogenously provided as cytokine-cytokine receptor pairs that improve adoptive immunotherapy.
机译:本公开的实施方案涵盖与用特定的免疫效应细胞作为过继免疫疗法和/或用免疫效应细胞能够结合的可溶性蛋白治疗癌症有关的方法和组合物。在一些情况下,可溶性蛋白是分子衔接子,其允许靶向缺乏过继免疫疗法针对的肿瘤抗原表达的癌细胞。在一些实施方案中,可溶性蛋白作为改善过继免疫疗法的细胞因子-细胞因子受体对被外源提供。

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