SCREENING METHOD FOR THERAPEUTIC SUBSTANCE FOR PREVENTING OR TREATING BRONCHOPULMONARY DYSPLASIA (BPD)

摘要

The present invention relates to a screening method for a therapeutic agent for pulmonary damage induced by the administration of high-concentration oxygen, and more specifically, to a screening method for a candidate material for a therapeutic agent for bronchopulmonary dysplasia (BPD) induced by the administration of high-concentration oxygen. The present inventors have discovered that FPR1 is over-expressed in lung tissues exposed to high-concentration oxygen, and in light of the correlation between the expression of FPR1 and the development of BPD, have confirmed that BPD can be suppressed by inhibiting the expression or activity of FPR1. In view of this fact, a prophylactic or therapeutic material for BPD may be discovered in a rapid and accurate manner by checking inhibition on the expression or activity level of FPR1, and thus, the screening method of the present invention may be beneficially used to effectively select and develop therapeutic agents for BPD.