Beto cells generated from memory T cells

摘要

A method for producing an isolated population of non-graft-versus-host disease (GvHD) -induced cells comprising a central memory T-lymphocyte (Tcm) phenotype, said cell being a resistance inducing cell and / or having an anti- , And can be homed to the lymph nodes after transplantation. The method comprising: (a) preparing a population of 70% or more memory T cells; (b) contacting the population of said memory T cells with an antigen or antigens to concentrate the antigen-reactive cells; (c) culturing the cells obtained from step (b) in the presence of cytokine to proliferate cells containing a central memory T-lymphocyte (Tcm) phenotype to generate an isolated population of non-GvHD induced cells . Cells, pharmaceutical compositions and methods of treatment produced by the above methods are also disclosed.