Use of ADAMTS13 for the treatment, improvement and / or prevention of vascular occlusion in sickle cell disease, acute lung injury and / or acute respiratory distress syndrome

摘要

The present disclosure also provides methods and compositions for treating or preventing vascular occlusion (VOC) in subjects suffering from sickle cell disease (SCD). The present disclosure also relates to methods of treating acute lung injury (ALI) and / or acute respiratory distress syndrome ADAMTS13 for treating, ameliorating and / or preventing lung injury in a subject suffering from or at risk of suffering from ARDS. The present disclosure relates to a method for treating, ameliorating and / or preventing pulmonary damage in a subject suffering from or at risk of suffering from ALI and / or ARDS, comprising administering a therapeutically effective amount of a disintegrin and metalloproteinase (ADAMTS13) or ADAMTS13.