Chimeric antigen receptor-effector cell switches with humanized targeting moieties and / or optimized chimeric antigen receptor-interacting domains and uses thereof

摘要

The disclosure provides a humanized targeting moiety that binds CD19 on a target cell and a humanized chimeric receptor effector cell switch comprising a chimeric receptor-interacting domain that binds to the chimeric receptor effector cell and / or an optimized chimeric receptor- Kit, and platform for selectively activating and deactivating chimeric receptor effector cells using a chimeric receptor-effector cell switch comprising a chimeric receptor-effector cell-domain. Methods of treating diseases and conditions with such chimeric receptor effector cells and chimeric receptor effector cell switches are also disclosed.