Use of designer receptors exclusively activated by designer drugs in the treatment of seizure disorders

摘要

Administering to the patient a vector encoding the modified receptor for delivery of the modified receptor to the target location, where the modified receptor is modified to be activated by a synthetic ligand, where the modified receptor inhibits neuronal firing when activated. Making; And compositions and methods for treating seizure disorders comprising administering a synthetic ligand to a patient. The modified receptor is also modified to be activated by a synthetic ligand, where the modified receptor delivers a vector encoding the modified receptor to the patient for delivery of the modified receptor to the target site, which increases neuronal ignition when activated. ; And compositions and methods are provided for treating seizure disorders in a patient in need thereof by administering the synthetic ligand to the patient. Methods are used to alleviate or ameliorate one or more symptoms of a seizure disorder.