- Pharmaceutical composition for preventing or treating cancer comprising coordination-driven self-assembly using thiophene-derived donor and arene-ruthenium acceptors

摘要

The present invention relates to a pharmaceutical composition for the prevention or treatment of cancer diseases containing as an active ingredient a thiophene-derived donor and a self-assembling compound using an arene-ruthenium receptor. In the present invention, a thiophene-derived donor and an arene- The self-assembled macrocyclic compound inhibited the cell proliferation of HepG2 cell line, which is a liver cancer cell line, and inhibited cell proliferation of poly (ADP-ribose) polymerase (PARP) Promoting the cleavage of caspase-3 and caspase-8, and increasing the expression ratio of Bax / Bcl-2 to activate extracellular and endogenous apoptotic pathways, thereby inducing apoptosis of cancer cells. Therefore, the self-assembled macrocyclic compound of the present invention having the above-mentioned effects can be usefully used as a pharmaceutical composition for preventing or treating cancer diseases.