Peptide compositions and methods for treating lung injury asthma anaphylaxis angioedema systemic vascular permeability syndromes and nasal congestion

摘要

Provided herein are peptide inhibitors for the interaction between terminal binding protein 3 (EB3) and inositol 1,4,5-tris phosphate receptor type 3 (IP ₃ R ₃ ). Also provided are methods and materials for treating lung injury, including acute lung injury. Lung damage can include permeability of pulmonary vessels, vascular leakage, the development of edema, asthma, anaphylaxis, angioedema, systemic vascular permeability syndrome and nasal congestion.