AGENT FOR TREATING HUMAN BODY CONDITIONS ASSOCIATED WITH A DECREASE IN THE LEVEL OF EXPRESSION OF THE PROK 2 GENE AND/OR A DECREASE IN THE AMOUNT OF PROKINETICIN 2 PROTEIN ON THE BASIS OF GENE-THERAPEUTIC SUBSTANCES WITH PROK 2 GENE, METHOD FOR OBTAINING AND USING

摘要

FIELD: medicine.SUBSTANCE: group of inventions refers to medicine and relates to an agent for treating conditions of cells of various organs and tissues, as well as the human organs and tissues associated with a decrease in the expression of the PROK 2 gene and/or a decrease in the amount of prokineticin 2 protein, based on gene-therapeutic substances with a PROK 2 gene representing at least one gene-therapeutic substance selected from the group of gene-therapeutic substances, each of which represents a genetic construct based on a vector plasmid comprising the cDNA of PROK 2 gene, with the prokineticin 2 protein coding sequence. Group of inventions also relates to a method for preparation of said agent for treating the human body conditions associated with a decrease in PROK 2 gene expression and/or decrease in the amount of prokineticin 2 protein; a method of using said agent to treat conditions of the human body associated with a decrease in PROK 2 gene expression and/or a decrease in the amount of prokineticin 2 protein.EFFECT: group of inventions provides the creation of a highly effective agent for treating the human body conditions associated with a decrease in the PROK 2 gene expression and/or a decrease in the amount of prokineticin 2 protein, based on gene-therapy substances with the PROK 2 gene.5 cl, 18 ex, 20 dwg