METHOD OF DETECTING POLYCOMB REPRESSIVE COMPLEX ACTIVITY

摘要

The present invention provides a method of detecting Polycomb Repressive Complex (PRC) activity in a cell providing a cell with a DNA having a protein binding site and at least one reporter gene expression site is operatively connected to said protein binding site, and with a DNA comprising a recombinant gene of a binding protein, said binding protein being capable of binding to said protein binding site, wherein said binding protein is fused to a member of the PRC, said method comprising the step of expressing said recombinant gene, letting said fused binding protein bind to said protein binding site and detecting at least one reporter gene expression.