MANUFACTURING METHOD OF CRYSTAL ETHYNYL GROUP SUBSTITUTED HYPERVALENT IODINE COMPOUND, AND INTRODUCTION METHOD OF ETHYNYL GROUP INTO AMINO GROUP USING THE SAME

摘要

To provide an effective introduction method of an ethynyl group in fields of organic synthesis and chemical biology by stabilizing ethynyl benziodoxolone which is highly thermally unstable.SOLUTION: The above described problem is solved by isolating as a crystal ethynyl benziodoxolone complex stabilized by taking a solvent X into ethynyl benziodoxolone and letting n X represented by the following formula (1) coordinate and using the same in a reaction for introducing an ethynyl group. Ris hydrogen, an alkyl group having a linear or branched structure constituted by C1 to C5 carbon atom, a chloro group, a bromo group, a fluoro group, a nitro group, and a cyano group, X is acetonitrile, chloroform, ethyl acetate, water, n is molecular number of a solvent represented by any integer or fraction, and a crystal composition is formed by being taken into a crystal ethynyl substituted hypervalent iodine.SELECTED DRAWING: None