CONSTITUTIVE EXPRESSION OF COSTIMULATORY LIGANDS ON ADOPTIVELY TRANSFERRED T LYMPHOCYTES

摘要

To provide immunoresponsive cells including T cells, cytotoxic T cells, regulatory T cells, and Natural Killer (NK) cells and expressing at least either of an antigen- recognizing receptor and a co-stimulatory ligand.SOLUTION: Provided are an immune-responsive cell comprising a receptor that binds to an antigen and an exogenous costimulatory ligand, and a virus-specific T cell expressing a vector encoding a polypeptide selected from the group consisting of CD80, 4-1BBL, OX40L, CD70 and CD30L, as well as a method for producing an antigen-specific immunoreactive cell comprising introducing a nucleic acid sequence encoding a chimeric antigen receptor into the immune-responsive cell, the chimeric antigen receptor comprising an antigen-binding domain that binds to an intracellular signaling domain that activates the immune-responsive cell.SELECTED DRAWING: None