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QUINONE COMPOUND FOR TREATING APE1 MEDIATED DISEASES

机译:喹诺酮类化合物治疗APE1介导的疾病

摘要

To provide a compound for treating Ape1 mediated diseases.SOLUTION: There is provided a compound represented by the following formula or a pharmaceutically acceptable salt thereof. In the formula, Rrepresents two substituents selected from H and alkoxy independently and H is not both R, or Rrepresents a condensed aryl ring optionally substituted, R is H or halo, or alkyl, alkoxy or the like, X is alkylene, alkenyl, or alkynylene, and Y is N(R)or NROR, Ris alkyl or the like, both of Rare together with nitrogen added for forming an optionally substituted heterocycle, Ris H, alkyl, or the like, or both of Rare together with N and O added for forming the optionally substituted heterocycle.SELECTED DRAWING: None
机译:提供用于治疗Ape1介导的疾病的化合物。解决方案:提供由下式表示的化合物或其药学上可接受的盐。式中,R表示独立地选自H和烷氧基的两个取代基,并且H不都是R,或者R表示任选取代的稠合芳基环,R是H或卤素,或烷基,烷氧基等,X是亚烷基,烯基或亚炔基,且Y为N(R)或NROR,Ris烷基等,Rare两者均与添加的氮一起形成任选取代的杂环,Ris H,烷基等,或Rare两者均与N和O一起添加以形成可选取代的杂环。

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