Methods and compositions related to improved human erythrocyte survival in genetically modified immunodeficient non-human animals

摘要

According to an aspect of the present invention, a genetically modified immunodeficient non-human animal, wherein the genome of said non-human animal macrophages and A genetically modified immunodeficient non-human animal comprising a genetic modification that deficient macrophage anti-human erythrocyte activity is provided. A method for assaying the effect of a therapeutic agent envisioned in such genetically modified immunodeficient non-human animals is provided by the present invention. In one aspect, the genetically modified immunodeficient non-human animal is a Lystnull immunodeficient mouse.