Human-derived interleukin-6 siRNA, recombinant expression CAR-T vector, and its construction method and use

摘要

The present invention provides human-derived interleukin-6 siRNA, recombinantly expressed CAR-T vector and methods and uses thereof. The siRNA is used not only to eliminate or reduce the symptoms of cytokine release syndrome (CRS) in the treatment of CAR19-T acute B lymphoblastic leukemia, but also to relieve CRS symptoms that occur when treating tumors with CAR-T treatment It can also be used to relieve CRS with other types of treatment.