Glycoproteins with low acetylation rate sialic acid residues

摘要

A method or process for producing a glycoprotein with modified efficacy that interacts with or acts as an agonist on an erythropoietin receptor (EpoR), wherein the heterologous of said glycoprotein in an appropriate expression system It relates to a method or process in which at least one step involving expression and resulting in a low acetylation rate sialic acid residue in said glycoprotein is provided (FIG. 16).