A humanized mouse model with improved human innate immune cell development

摘要

A transgenic immunodeficient mouse is provided with the method of use, wherein the mouse encodes (a) a nucleotide sequence encoding human stem cell factor (hSCF); (b) a human granulocyte macrophage colony stimulating factor (hGM-CSF) (C) a nucleotide sequence encoding human interleukin-3 (hIL-3); and (d) a nucleotide sequence encoding human colony stimulating factor 1 (hCSF1), wherein the nucleotide sequence Each is operably linked to a promoter, the transgenic immunodeficient mouse expresses hSCF, hGM-CSF, hIL-3, and hCSF1, and the transgenic immunodeficient mouse expresses human hematopoietic stem cell production. Tumor xenografts from human patients and / or human tumor cells Engraftment of shares to allow the investigation of the in vivo interaction between the cancer of the immune system and the human person.