Method for treating irritable bowel syndrome with modified or delayed release formulation of linaclotide

摘要

The present invention provides a method for treating a patient having a condition, such as a GI disorder, or a GI or non-GI disorder, by administering a therapeutically effective amount of a delayed release pharmaceutical composition comprising linaclotide. . Despite the need for delayed release compositions of linaclotide, due to the inherent chemical instability of linaclotide, for example, moisture-induced degradation reactions such as hydrolysis, deamidation, isomerization and Due to multimerization, there are difficulties in preparing such formulations. The present application provides means for solving this problem.