Thienopyranones and furanopyranones as kinases, bromodomains and checkpoint inhibitors

摘要

Kind Code: A1 Abstract: Thienopyranones and furanopyranones as kinases, bromodomains and checkpoint inhibitors. Kind Code: A1 The present invention is not limited by modulating biological processes by inhibiting the binding of cell cycle checkpoint targets to CDK, and / or PI3 kinase, and / or bromodomain proteins to substrates. Compounds and methods for treating cancer, non-cancer proliferative disease, sepsis, autoimmune disease, viral infection, atherosclerosis, type 1 or type 2 diabetes, obesity, inflammatory disease or disease including Myc-dependent disorder Thus, the methods relate to compounds and methods that include the administration of a compound of Formulas 1-V1 (or a pharmaceutically acceptable salt thereof) as defined herein. [Selection diagram] None