Inhibition of caspase-1 and its use for prevention and treatment of neurological conditions

摘要

Preventing a neurological condition (eg, a neurodegenerative disease (eg, Alzheimer's disease)) in a subject, delaying its onset or reducing its severity, preventing its progression, or preventing its progression, based on caspase 1 inhibition Methods for retreating or treating are described herein. Also described herein are methods of preventing cognitive impairment, delaying its onset or reducing its severity, preventing or reversing its progression, or treating its progression in a subject based on caspase-1 inhibition. . Corresponding uses and kits are also described. In one embodiment, the caspase 1 inhibitor is VX-765 or a pharmaceutically acceptable salt thereof.