首页> 外国专利> Method for producing transformed plant producing immunogenic complex protein and immunogenic complex protein obtained therefrom

Method for producing transformed plant producing immunogenic complex protein and immunogenic complex protein obtained therefrom

机译:产生转化的植物的方法,所述转化的植物产生免疫原性复合蛋白和由此获得的免疫原性复合蛋白

摘要

The present invention relates to a method for manufacturing a transgenic plant producing immunogenic complex proteins and immunogenic complex proteins obtained therefrom and, more specifically, to a method for manufacturing a transgenic plant producing immunogenic complex proteins, a plant manufactured by the method, and immunogenic complex proteins obtained from the plant, wherein the method comprises the steps of: (a) manufacturing a transgenic plant expressing an antigen; (b) manufacturing a transgenic plant expressing an antibody specific to the antigen in step (a); and (c) cross-breeding the plants in steps (a) and (b) to manufacture a cross-bred plant. Immunogenic complex proteins can be mass-produced through the method for manufacturing a transgenic plant, comprising steps (a) to (c), and the transgenic plant manufactured by the method, of the present invention. Further, the immunogenic complex proteins (antigen-antibody complex) obtained from the plant have a gigantic four-dimensional structure, thereby having an excellent immune reaction boosting effect, thus exhibiting an excellent antibody producing capacity in a host animal, even without the use of an immune adjuvant.
机译:本发明涉及生产产生免疫原性复合蛋白的转基因植物的方法和由其获得的免疫原性复合蛋白,更具体地说,涉及生产产生免疫原性复合蛋白的转基因植物的方法,用该方法生产的植物和免疫原性复合物从植物获得的蛋白质,其中该方法包括以下步骤:(a)制造表达抗原的转基因植物; (b)在步骤(a)中制造表达对该抗原特异的抗体的转基因植物; (c)在步骤(a)和(b)中对植物进行杂交育种以生产杂交植物。免疫原性复合蛋白可以通过包括步骤(a)至(c)的本发明的转基因植物的制造方法和通过该方法制造的转基因植物来大量生产。此外,从植物获得的免疫原性复合蛋白(抗原-抗体复合物)具有巨大的四维结构,从而具有优异的免疫反应促进作用,因此即使不使用大肠杆菌也表现出优异的宿主动物抗体产生能力。免疫佐剂。

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