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Genetic encoding of chemical post-translational modification for phage-displayed libraries
Genetic encoding of chemical post-translational modification for phage-displayed libraries
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机译:噬菌体展示文库化学翻译后修饰的遗传编码
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摘要
The present application provides a method of synthesizing a genetically-encoded chemical modification of a peptide library. A vector in a substrate, such as a phage, is modified to include a peptide linker and a modification to form a genetic “barcode”. The barcode is screened against potential targets which may be used in drug discovery.
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