Composition of materials containing fluoride varnish and antibacterial agents for prevention and treatment of dental caries

摘要

The present invention relates to a pharmaceutical composition for prevention and treatment of dental caries comprising a fluoride varnish and an antibacterial substance as active ingredients. The fluoride varnish composition comprising xanthorrhizol, bakuchiol, bavachalcone, isobavachromene or bavachromene according to the present invention exhibits significant antibacterial activities against the strain Streptococcus mutans (S. mutans), which causes dental caries. In particular, the composition exhibits remarkable antibacterial activities compared xanthorrhizol, bakuchiol, bavachalcone, isobavachromene, bavachromene or a fluoride varnish. Therefore, the fluoride varnish comprising xanthorrhizol, bakuchiol, bavachalcone, isobavachromene or bavachromene can be usefully used for prevention and treatment of dental caries.