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FK506 derivative maintaining nerve regeneration activity without immunosuppressive activity, and use thereof
FK506 derivative maintaining nerve regeneration activity without immunosuppressive activity, and use thereof
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机译:保持神经再生活性而不具有免疫抑制活性的fk506衍生物及其用途
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摘要
The present invention relates to an FK506 derivative which has reduced immunosuppressive activity but maintains nerve regeneration activity, a preparing method thereof, and a pharmaceutical composition comprising the same for preventing or treating nervous system diseases. A composition comprising 9-deoxo-prolyl-FK506, 31-O-demethyl-FK506, or 9-deoxo-31-O-demethyl-FK506 can promote nerve regeneration and has reduced immunosuppressive activity, thereby reducing side effects in the treatment of nervous system diseases.
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