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Inhibitors of Base Excision Repair Activity and Therapeutic Methods Based Thereon
Inhibitors of Base Excision Repair Activity and Therapeutic Methods Based Thereon
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机译:根基切除修复活性抑制剂及基于其的治疗方法
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摘要
Noncovalent small-molecule inhibitors of the enzyme OGG1, methods of their manufacture, and applications for their administration are provided. Small molecule inhibitors were shown to be selective for inhibiting OGG1 over multiple repair enzymes, including other base excision repair enzymes, and it displayed no toxicity in two human cell lines. The inhibitors provide a tool for the study of the role of OGG1 in multiple disease-related pathways, and a therapeutic target for the treatment thereof.
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