STAGED-RETENTION METHOD FOR UPSTREAM PRODUCTION OF BIOMACROMOLECULES, PRODUCTION MODULE USED THEREIN AND APPLICATION THEREOF IN PRODUCTION

摘要

The present disclosure provides a staged-retention method for upstream production of biomacromolecules, a production module used therein, and an application of the method/module in the industrial production of polypeptides, fusion proteins and immunoglobulin molecules. The method of the present disclosure can effectively improve the upstream production efficiency, yield and purity in the large-scale production of a recombinant protein.