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DUAL MODALITY UPS NANOPROBES FOR TUMOR ACIDOSIS IMAGING
DUAL MODALITY UPS NANOPROBES FOR TUMOR ACIDOSIS IMAGING
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机译:用于肿瘤酸成像的双模UPS纳米探针
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摘要
The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH as well as a metal chelating group. In some aspects, the metal chelating group is chelated to a metal ion capable of positron emission. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
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