NPRA AGONISTS, COMPOSITIONS, AND USES THEREOF

摘要

This disclosure provides a natriuretic peptide derivative of Formula (I), and to compositions including a natriuretic peptide derivative of Formula (I),; (fatty acyl)_z-(B)_x-(G)_y-NP   (I),;wherein: z is 1, x is an integer from 2 to 4 and y is 3; or z is 0, x is an integer from 0 to 4 and y is an integer from 1 to 3; fatty acyl comprises from 12 to 24 (e.g., 12 to 18) carbons atoms; B is lysine or arginine; G is glycine; NP is a natriuretic peptide; if present, (fatty acyl)_z- is covalently linked to the N-terminus of (B)_x; (fatty acyl)_z-(B)_x- is covalently linked to the N-terminus of (G)_y; and (fatty acyl)_z-(B)_x-(G)_y- is covalently linked to the N-terminus of NP. The natriuretic peptide derivative according to the disclosure, and compositions thereof, are useful in the treatment of diseases such as hypertension, vascular congestion, and heart disease.