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PENTOSAN POLYSULFATE AND METHOD FOR PRODUCING PENTOSAN POLYSULFATE

机译:戊聚糖聚硫酸盐和生产戊聚糖聚硫酸盐的方法

摘要

The present invention provides a pentosan polysulfate having a uronic acid content of 0.0% by mass to 6.0% by mass, preferably a pentosan polysulfate having a structure represented by Formula I:; embedded image ;wherein each R represents a hydrogen atom, —COCH3 or —SO3X, and at least one R represents —SO3X, wherein X represents a hydrogen atom or a monovalent or divalent metal, and n represents an integer of 1 or more and 30 or less; a pharmaceutically acceptable salt thereof; or a pharmaceutically acceptable solvate of the pentosan polysulfate or of a pharmaceutically acceptable salt thereof. The present invention further provides a method for producing pentosan polysulfate, the method comprising the steps of depolymerizing a plant-derived raw material to obtain neutral xylooligosaccharide and sulfating the neutral xylooligosaccharide, in this order.
机译:本发明提供具有0.0质量%至6.0质量%的糖醛酸含量的戊聚糖多硫酸盐,优选具有式I表示的结构的戊聚糖多硫酸盐: “嵌入式图像” ;其中每个R代表氢原子,-COCH 3 或-SO 3 X,并且至少一个R代表-SO 3 X,其中X表示氢原子或一价或二价金属,n表示1以上且30以下的整数。其药学上可接受的盐;或其戊聚糖多硫酸盐或其药学上可接受的盐的药学上可接受的溶剂化物。本发明进一步提供一种生产戊聚糖多硫酸盐的方法,该方法包括以下步骤:将植物来源的原料解聚以获得中性低聚木糖,并依次硫酸化中性低聚木糖。

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